-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, L4J5PhBvbEdRS91P8ZP/OBOMIzyZZ5entT3MyVcEnheA1Fk4lfYuX2W9e1KfdMIW B6aKaDd6QVBtdKmYGpPctQ== 0001144204-07-007619.txt : 20070214 0001144204-07-007619.hdr.sgml : 20070214 20070214114618 ACCESSION NUMBER: 0001144204-07-007619 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 4 FILED AS OF DATE: 20070214 DATE AS OF CHANGE: 20070214 GROUP MEMBERS: D. E. SHAW & CO., L.L.C. GROUP MEMBERS: D. E. SHAW & CO., L.P. GROUP MEMBERS: DAVID E. SHAW SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: Hana Biosciences Inc CENTRAL INDEX KEY: 0001140028 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 841588441 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: 1934 Act SEC FILE NUMBER: 005-79910 FILM NUMBER: 07615981 BUSINESS ADDRESS: STREET 1: 7000 SHORELINE COURT STREET 2: SUITE 370 CITY: SOUTH SAN FRANCISCO STATE: CA ZIP: 94080 BUSINESS PHONE: 6505886404 MAIL ADDRESS: STREET 1: 7000 SHORELINE COURT STREET 2: SUITE 370 CITY: SOUTH SAN FRANCISCO STATE: CA ZIP: 94080 FORMER COMPANY: FORMER CONFORMED NAME: EMAIL REAL ESTATE COM INC DATE OF NAME CHANGE: 20010504 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: D. E. Shaw Meniscus Portfolios, L.L.C. CENTRAL INDEX KEY: 0001324348 IRS NUMBER: 510481096 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: 39TH FLOOR, TOWER 45 STREET 2: 120 WEST FORTY-FIFTH STREET CITY: NEW YORK STATE: NY ZIP: 10036 BUSINESS PHONE: 212-478-0000 MAIL ADDRESS: STREET 1: 39TH FLOOR, TOWER 45 STREET 2: 120 WEST FORTY-FIFTH STREET CITY: NEW YORK STATE: NY ZIP: 10036 FORMER COMPANY: FORMER CONFORMED NAME: D.E. Shaw Meniscus Portfolios, L.L.C. DATE OF NAME CHANGE: 20050420 SC 13G/A 1 v064570_sc13ga.htm

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

(Amendment No. 1)

Under the Securities Exchange Act of 1934

Hana Biosciences, Inc.

(Name of Issuer)

Common Stock, $0.001 par value

(Title of Class of Securities)

268749108

(CUSIP Number)

December 31, 2006

(Date of Event Which Requires Filing of this Statement)

Check the following box to designate the rule pursuant to which the Schedule is filed:

o	Rule 13d-1(b)
x	Rule 13d-1(c)
o	Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 268749108

	1.	Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) D. E. Shaw Meniscus Portfolios, L.L.C. 51-0481096

	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o

	3.	SEC Use Only

	4.	Citizenship or Place of Organization Delaware

Number of Shares Beneficially Owned by Each Reporting Person With			5.	Sole Voting Power -0-

			6.	Shared Voting Power 2,283,085

			7.	Sole Dispositive Power -0-


			8.	Shared Dispositive Power 2,283,085

	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 2,283,085

	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o

	11.	Percent of Class Represented by Amount in Row (9) 7.9%

	12.	Type of Reporting Person (See Instructions) OO

CUSIP No. 268749108

	1.	Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) D. E. Shaw & Co., L.L.C. 13-3799946

	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o

	3.	SEC Use Only

	4.	Citizenship or Place of Organization Delaware

Number of Shares Beneficially Owned by Each Reporting Person With			5.	Sole Voting Power -0-

			6.	Shared Voting Power 2,283,085

			7.	Sole Dispositive Power -0-

			8.	Shared Dispositive Power 2,283,085

	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 2,283,085

	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o

	11.	Percent of Class Represented by Amount in Row (9) 7.9%

	12.	Type of Reporting Person (See Instructions) OO

CUSIP No. 268749108

	1.	Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) D. E. Shaw & Co., L.P. 13-3695715

	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o

	3.	SEC Use Only

	4.	Citizenship or Place of Organization Delaware

Number of Shares Beneficially Owned by Each Reporting Person With			5.	Sole Voting Power -0-

			6.	Shared Voting Power 2,600,812

			7.	Sole Dispositive Power -0-

			8.	Shared Dispositive Power 2,600,812

	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 2,600,812

	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o

	11.	Percent of Class Represented by Amount in Row (9) 9.0%

	12.	Type of Reporting Person (See Instructions) IA, PN

CUSIP No. 268749108

	1.	Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) David E. Shaw

	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o

	3.	SEC Use Only

	4.	Citizenship or Place of Organization United States

Number of Shares Beneficially Owned by Each Reporting Person With			5.		Sole Voting Power -0-

			6.		Shared Voting Power 2,600,812

			7.		Sole Dispositive Power -0-

			8.		Shared Dispositive Power 2,600,812

	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 2,600,812

	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o

	11.	Percent of Class Represented by Amount in Row (9) 9.0%

	12.	Type of Reporting Person (See Instructions) IN

Item 1.

	(a)	Name of Issuer
		Hana Biosciences, Inc.

	(b)	Address of Issuer's Principal Executive Offices
		400 Oyster Point Boulevard, Suite 215 South San Francisco, CA 94080

	(b)				Address of Principal Business Office or, if none, Residence
					The business address for each reporting person is: 120 W. 45^th Street, Tower 45, 39^th Floor New York, NY 10036

	(c)				Citizenship
					D. E. Shaw Meniscus Portfolios, L.L.C. is a limited liability company organized under the laws of the state of Delaware. D. E. Shaw & Co., L.L.C. is a limited liability company organized under the laws of the state of Delaware. D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware. David E. Shaw is a citizen of the United States of America.

	(d)				Title of Class of Securities
					Common Stock, $0.001 par value

	(e)				CUSIP Number
					268749108

As of December 31, 2006:

(a) Amount beneficially owned:

D. E. Shaw Meniscus Portfolios, L.L.C.:		2,283,085 shares

D. E. Shaw & Co., L.L.C.:		2,283,085 shares This is composed of 2,283,085 shares in the name of D. E. Shaw Meniscus Portfolios, L.L.C.

D. E. Shaw & Co., L.P.:		2,600,812 shares This is composed of (i) 2,283,085 shares in the name of D. E. Shaw Meniscus Portfolios, L.L.C. and (ii) 317,727 shares in the name of D. E. Shaw Valence Portfolios, L.L.C.

David E. Shaw:		2,600,812 shares This is composed of (i) 2,283,085 shares in the name of D. E. Shaw Meniscus Portfolios, L.L.C. and (ii) 317,727 shares in the name of D. E. Shaw Valence Portfolios, L.L.C.

(b) Percent of class:

D. E. Shaw Meniscus Portfolios, L.L.C.:		7.9%
D. E. Shaw & Co., L.L.C.:		7.9%
D. E. Shaw & Co., L.P.:		9.0%
David E. Shaw:		9.0%

(i) Sole power to vote or to direct the vote:

D. E. Shaw Meniscus Portfolios, L.L.C.:		-0- shares
D. E. Shaw & Co., L.L.C.:		-0- shares
D. E. Shaw & Co., L.P.:		-0- shares
David E. Shaw:		-0- shares

(ii) Shared power to vote or to direct the vote:

D. E. Shaw Meniscus Portfolios, L.L.C.:		2,283,085 shares
D. E. Shaw & Co., L.L.C.:		2,283,085 shares
D. E. Shaw & Co., L.P.:		2,600,812 shares
David E. Shaw:		2,600,812 shares

(iii) Sole power to dispose or to direct the disposition of:

D. E. Shaw Meniscus Portfolios, L.L.C.:		-0- shares
D. E. Shaw & Co., L.L.C.:		-0- shares
D. E. Shaw & Co., L.P.:		-0- shares
David E. Shaw:		-0- shares

(iv) Shared power to dispose or to direct the disposition of:

D. E. Shaw Meniscus Portfolios, L.L.C.:		2,283,085 shares
D. E. Shaw & Co., L.L.C.:		2,283,085 shares
D. E. Shaw & Co., L.P.:		2,600,812 shares
David E. Shaw:		2,600,812 shares

David E. Shaw does not own any shares directly. By virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the managing member and investment adviser of D. E. Shaw Valence Portfolios, L.L.C. and the investment adviser of D. E. Shaw Meniscus Portfolios, L.L.C., and by virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the managing member of D. E. Shaw Meniscus Portfolios, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of, and the shared power to dispose or direct the disposition of, the 2,600,812 shares as described above constituting 9.0% of the outstanding shares and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 2,600,812 shares.

Item 5.		Ownership of Five Percent or Less of a Class

Not applicable

Item 6.		Ownership of More than Five Percent on Behalf of Another Person.

Not Applicable

Item 7.		Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

Not Applicable

Item 8.		Identification and Classification of Members of the Group

Not Applicable

Item 9.		Notice of Dissolution of Group

Not Applicable

Item 10.		Certification

By signing below, each of D. E. Shaw Meniscus Portfolios, L.L.C., D. E. Shaw & Co., L.L.C., D. E. Shaw & Co., L.P., and David E. Shaw certify that, to the best of such reporting person’s knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purposes or effect.

SIGNATURE

After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. Powers of Attorney, dated February 24, 2004, granted by David E. Shaw in favor of Anne Dinning, are attached hereto.

Dated: February 14, 2007


	D. E. Shaw Meniscus Portfolios, L.L.C.
	By:	D. E. Shaw & Co., L.L.C., as managing member


	By:	/s/ Anne Dinning
		Anne Dinning
		Managing Director



	D. E. Shaw & Co., L.L.C.

	By:	/s/ Anne Dinning
		Anne Dinning
		Managing Director



	D. E. Shaw & Co., L.P.

	By:	/s/ Anne Dinning
		Anne Dinning
		Managing Director



	David E. Shaw

	By:	/s/ Anne Dinning
		Anne Dinning
		Attorney-in-Fact for David E. Shaw

EX-1 2 v064570_ex1.htm

Exhibit 1

POWER OF ATTORNEY

FOR CERTAIN FILINGS

UNDER THE SECURITIES EXCHANGE ACT OF 1934

I, David E. Shaw, hereby make, constitute and appoint each of:

Anne Dinning,

Julius Gaudio,

Lou Salkind,

Stuart Steckler, and

Eric Wepsic,

acting individually, as my agent and attorney-in-fact, with full power of substitution, for the purpose of, from time to time, executing in my name and/or my capacity as President of D. E. Shaw & Co., Inc. (acting for itself or as the general partner of D. E. Shaw & Co., L. P. and general partner or managing member of other entities, any which in turn may be acting for itself or other entities) all documents, certificates, instruments, statement, other filings, and amendments to the forgoing (collectively, “documents”) determined by such person to be necessary or appropriate to comply with ownership or control-person reporting requirements imposed by any United States or non-United States governmental or regulatory authority, including without limitation Forms 3, 4, 5, 13D, 13F, and 13G required to be filed with the Securities and Exchange Commission; and delivering, furnishing or filing any such documents with the appropriate governmental or regulatory authority. Any such determination shall be conclusively evidenced by such person’s execution, delivery, furnishing, and/or filing of the applicable document.

This power of attorney shall be valid from the date hereof and replaces the power granted on February 5, 2001, which is hereby cancelled.

IN WITNESS HEREOF, I have executed this instrument as of the date set forth below.

Date: February 24, 2004

DAVID E. SHAW, as President of

D. E. Shaw & Co., Inc.

/s/ David E. Shaw

New York, New York

EX-2 3 v064570_ex2.htm

Exhibit 2

POWER OF ATTORNEY

FOR CERTAIN FILINGS

UNDER THE SECURITIES EXCHANGE ACT OF 1934

I, David E. Shaw, hereby make, constitute and appoint each of:

Anne Dinning,

Julius Gaudio,

Lou Salkind,

Stuart Steckler, and

Eric Wepsic,

acting individually, as my agent and attorney-in-fact, with full power of substitution, for the purpose of, from time to time, executing in my name and/or my capacity as President of D. E. Shaw & Co. II, Inc. (acting for itself and as the managing member of D. E. Shaw & Co., L.L.C., which in turn may be acting for itself or as the managing member of other companies) all documents, certificates, instruments, statement, other filings and amendments to the forgoing (collectively, “documents”) determined by such person to be necessary or appropriate to comply with ownership or control-person reporting requirements imposed by any United States or non-United States governmental or regulatory authority, including without limitation Forms 3, 4, 5, 13D, 13F and 13G required to be filed with the Securities and Exchange Commission; and delivering, furnishing or filing any such documents with the appropriate governmental or regulatory authority. Any such determination shall be conclusively evidenced by such person’s execution and delivery, furnishing or filing of the applicable document.

This power of attorney shall be valid from the date hereof and replaces the power granted on February 5, 2001, which is hereby cancelled.

IN WITNESS HEREOF, I have executed this instrument as of the date set forth below.

Date: February 24, 2004

DAVID E. SHAW, as President of

D. E. Shaw & Co. II, Inc.

/s/ David E. Shaw

New York, New York

EX-3 4 v064570_ex3.htm

Exhibit 3

JOINT FILING AGREEMENT

In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, each of the undersigned Reporting Persons hereby agrees to the joint filing, along with all other such Reporting Persons, on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock, $0.001 par value, of Hana Biosciences, Inc., and that this Agreement be included as an Exhibit to such joint filing. This Agreement may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument.

IN WITNESS WHEREOF, each of the undersigned hereby executes this Agreement as of this 14th day of February, 2007.


	D. E. Shaw Meniscus Portfolios, L.L.C.
	By:	D. E. Shaw & Co., L.L.C., as managing member


	By:	/s/ Anne Dinning
		Anne Dinning
		Managing Director



	D. E. Shaw & Co., L.L.C.

	By:	/s/ Anne Dinning
		Anne Dinning
		Managing Director



	D. E. Shaw & Co., L.P.

	By:	/s/ Anne Dinning
		Anne Dinning
		Managing Director



	David E. Shaw

	By:	/s/ Anne Dinning
		Anne Dinning
		Attorney-in-Fact for David E. Shaw

-----END PRIVACY-ENHANCED MESSAGE-----

Item 2.

Name of Person Filing

D. E. Shaw Meniscus Portfolios, L.L.C.

D. E. Shaw & Co., L.L.C.

D. E. Shaw & Co., L.P.

David E. Shaw